A recombination between the short homologous regions of nucleotide sequences in the retroviral vector and packaging cell line has been thought to be a major cause of the production of ...

Despite the undeniable ability of viral vectors to deliver genetic payloads, and despite the incredible promise of this approach to treat a vast variety of diseases—including metabolic, cardiovascular ...

Viral vectors are vital for the cell and gene therapy industry. However, long production timelines, combined with quality and consistency issues, mean that growing demand is outstripping supply. The ...

Production of viral vectors requires a holistic view of the product, including its manufacturing process and its ultimate end use. Viral vectors must be free of contaminants, such as adventitious ...

Lentiviral vectors are versatile gene delivery tools, capable of transducing a wide range of cell types. However, producing large volumes of high-quality lentiviruses can present several challenges.